王晨轩，研究员，博士生导师。1986年生于北京。中国医学科学院基础医学研究所/北京协和医学院基础学院，生物物理与结构生物学系课题组长，院校准长聘教职系列，中国生物物理学会纳米生物学分会优秀青年学者（2023年）。在Sci Adv, PNAS, ACS Cent Sci, JACS,
Nano Lett等国际期刊上发表论文60余篇，获得国家专利授权16项。当前研究方向为疾病相关蛋白质折叠、组装、相变与调控。课题组隶属于重大疾病共性机制研究全国重点实验室。目前实验室有副研究员2人，培养研究生8人。主讲八年制与研究生课《生物物理学》，参与《纳米医学概论》、《化学生物学》、《生理学的物理分析》等研究生课教学任务。
联系方式
北京市东城区东单三条5号，老科研楼 461，邮编 100005
Email：wangcx@ibms.pumc.edu.cn
教育及工作经历
2004-2008年，兰州大学国家理科化学基地班，本科。
2008-2013年，中国科学院国家纳米科学中心与清华大学化学系联合培养研究生，物理化学专业。导师王琛研究员、杨延莲研究员、李艳梅教授。研究方向：淀粉样蛋白折叠结构的研究及多肽-药物相互作用。2013年获清华大学理学博士学位。
2010年，丹麦奥胡斯大学多学科交叉纳米中心访问学者，合作导师董明东教授。
2013-2018年，美国威斯康星大学麦迪逊校区化学系，化学与生物工程系博士后。合作导师美国工程院院士Nicholas L. Abbott教授，美国科学院院士Samuel H. Gellman教授。研究方向：多肽折叠结构与单分子力学研究。
2018至今，中国医学科学院基础医学研究所/北京协和医学院基础学院生物物理与结构生物学系，课题组长。历任副研究员、硕士生导师、研究员、博士生导师。研究方向：疾病相关蛋白质组装与调控
蛋白质的正确折叠与组装是维持人体生理机能的必需。肽链通过精密地调控分子间相互作用自组装形成有序三维分子结构，进一步组装、聚集、相分离，形成执行生理功能的分子机器与无膜细胞器。蛋白质组装稳态失衡是一系列退行性疾病共同的病理生理基础。研究蛋白质组装过程与结构，认识自组装过程中的分子间相互作用的本质与规律，实现对自组装过程与功能的有效调控对蛋白质组装相关疾病的预防和治疗有重要意义，从经典药物治疗到相关新型药物治疗的兴起，从微观层面对发病分子机理的阐述到宏观层面治疗模式的创新，新的认识将在未来改变相关疾病的诊治模式，为患者改善预后带来新的机遇。
课题组遵循“认识组装-调控组装-利用组装”的研究思路，发展扫描隧道显微术、原子力探针显微术、核磁共振波谱技术、X-射线单晶衍射、光散射等新颖的物理、物理化学方法用于生物大分子的结构测定，在单分子水平理解与重大疾病发生、发展密切相关的蛋白、多肽的折叠、组装结构和过程，认识蛋白、多肽折叠组装过程中的相互作用本质与调控规律。
当前，课题组开展的研究课题包括：
（1）蛋白质折叠、组装与分子识别的物理化学机制（Sci Adv, 2023; ACS Cent Sci, 2023; Nano Lett, 2023; Mater Today Phys, 2024; J Am Chem Soc, 2017; Nature, 2015）
（2）蛋白质折叠与组装调控的生物学与医学应用：靶向夏科-莱登晶体的药物干预及其在慢性鼻鼻窦炎治疗中的应用（Nano Lett, 2022）
（3）药物的选择性寡聚化识别淀粉样蛋白组装体的分子机制以及生物学功能（Sci Adv, 2020）
课题组导师团队
招生要求：
课题组开展多学科交叉研究，目前实验室成员的教育背景涵盖了生物学、化学、药学、物理、基础医学、检验医学、生物信息学、化学工程、材料科学、法医。欢迎生物学、生物技术、药学、基础医学、检验医学、生物工程、生物信息学及相关专业的学生报考。
招生要求：（1）本科专业主干课成绩优秀；（2）热爱科学研究与基础研究，对未知领域有强烈好奇心、献身精神；（3）有团队合作精神；（4）中文表达与写作能力优异，良好的普通话书面语沟通、交流与演讲能力；（5）英文读写能力合格，全国大学英语六级考试成绩及格。
课题组掠影
在读学生
已毕业学生
课题组历年发表论文
2024
Publications
64. Zhongyi
Jian#, Ruonan Wang#, Shanshan Mo, Zhun Deng, Shuyuan Li, Zhenyan Li, Mingzhan
Wang, Yanlian Yang, Chen Wang, Wenbo Zhang, Lanlan Yu*, Chenxuan
Wang*, Structural evolution of the conformational ensembles in peptide fibrillar
aggregates, Materials Today Physics, 2024, 44, 101437, DOI:
10.1016/j.mtphys.2024.101437.
2023
Publications
63. Wenbo
Zhang#, Ruonan Wang#, Mingwei Liu#, Shucong Li, Asher E. Vokoun, Weichen Deng,
Robert L. Dupont, Feiyi Zhang, Shuyuan Li, Yang Wang, Zhenyu Liu, Yongfang
Zheng, Shuli Liu, Yanlian Yang, Chen Wang, Lanlan Yu*, Yuxing Yao,
Xiaoguang Wang*, Chenxuan Wang*, Single-molecule visualization
determines conformational sub-state ensembles in β-sheet-rich peptide fibrils, Science
Advances, 2023, 9(27), eadg794, DOI: 10.1126/sciadv.adg7943.
62. Lanlan
Yu#, Ruonan Wang#, Shucong Li, Ufuoma I. Kara, Eric C. Boerner, Boyuan Chen,
Feiyi Zhang, Zhongyi Jian, Shuyuan Li, Mingwei Liu, Yang Wang, Shuli Liu,
Yanlian Yang, Chen Wang, Wenbo Zhang*, Yuxing Yao, Xiaoguang Wang*, Chenxuan Wang*, Experimental insights into conformational ensembles of
assembled sheet peptides, ACS Central Science, 2023, 9(7),
1480–1487, DOI: 10.1021/acscentsci.3c00230.
61. Wenbo
Zhang#, Mingwei Liu#, Yang Wang#, Xin Wang, Ruonan Wang, Shuyuan Li, Lanlan Yu,
Feiyi Zhang, Chenxuan Wang*, b-Sheet
assembly translates conservative single-site mutation into a perturbation in
macroscopic structure, Nano Letters, 2023, 23(6), 2370-2378, DOI:
10.1021/acs.nanolett.3c00311.
60. Chenxuan
Wang*, Lei Liu*, Xiaoguang Wang*, Editorial: the hierarchical
organization of supramolecular systems: from fundamentals to biomedical
applications, volume II, Frontiers in Bioengineering and Biotechnology,
2023, 11, 1177799, DOI: 10.3389/fbioe.2023.1177799.
2022
Publications
59. Meichen
Zhang#, Yangyang Ge#, Shilin Xu, Xiaocui Fang, Jie Meng, Lanlan Yu, Chenxuan
Wang, Jian Liu, Tao Wen, Yanlian Yang, Chen Wang*, Haiyan Xu*,
Nanomicelles co-loading CXCR4 antagonist and doxorubicin combat the refractory
acute myeloid leukemia, Pharmacological Research, 2022, 185,
106503, DOI: 10.1016/j.phrs.2022.106503.
58. Lanlan
Yu#, Ruonan Wang#, Tao Wen#, Lei Liu, Tao Wang, Shuli Liu, Haiyan Xu*, Chenxuan
Wang*, Peptide binder with high-affinity for the SARS-CoV-2 spike
receptor-binding domain, ACS Applied Materials & Interfaces,
2022, 14(25), 28527–28536, DOI: 10.1021/acsami.2c03707.
57. Yan
Zhao#, Shanshan Mo#, Lanlan Yu#, Xiaolu Li, Yun Hao, Wenbo Zhang, Qi Zhang,
Ping Wang, Xiangdong Wang*, Chenxuan Wang*, Luo Zhang*, Crystalline
state determines the potency of galectin-10 protein assembly to induce
inflammation, Nano Letters, 2022, 22(6), 2350-2357, DOI:
10.1021/acs.nanolett.1c04817.
56. Feiyi
Zhang#, Lanlan Yu#, Zhun Deng, Shuli Liu, Chenxuan Wang*, Lei Liu*,
Composition-dependent wettability of nature-inspired homo poly(amino acid)
coating and its influences on bacterial adhesion, European Polymer
Journal, 2022, 168, 111127, DOI: 10.1016/j.eurpolymj.2022.111127.
55. Wenbo
Zhang#, Mingwei Liu#, Lanlan Yu#, Shanshan Mo, Zhun Deng, Shuli Liu, Yanlian
Yang, Chen Wang, Chenxuan Wang*, Perturbation effect of single polar
group substitution on the self-association of amphiphilic peptide helices, Journal
of Colloid and Interface Science, 2022, 610, 1005-1014, DOI:
10.1016/j.jcis.2021.11.154.
54. Zhichao
Lou#, Qiuyi Wang, Xiaodi Zhou, Ufuoma I. Kara, Rajdeep S. Mamtani, Hualiang Lv*,
Meng Zhang, Zhihong Yang, Yanjun Li, Chenxuan Wang*, Solomon Adera*,
Xiaoguang Wang*, An angle-insensitive electromagnetic absorber enabling
a wideband absorption, Journal of Materials Science & Technology,
2022, 113, 33-39, DOI: 10.1016/j.jmst.2021.11.007.
2021
Publications
53. Wenbo
Zhang#, Mingwei Liu#, Robert L. Dupont, Kai Huang, Lanlan
Yu, Shuli Liu, Xiaoguang Wang*, Chenxuan Wang*, Conservation and
identity selection of cationic residues flanking the hydrophobic regions in
intermediate filament superfamily, Frontiers in Chemistry, 2021, 9,
752630, doi: 10.3389/fchem.2021.752630.
52. Feiyi
Zhang#, Lanlan Yu#, Wenbo Zhang#, Lei Liu*, Chenxuan Wang*, A minireview on the
perturbation effects of polar groups to direct nanoscale hydrophobic
interaction and amphiphilic peptide assembly, RSC Advances, 2021, 11,
28667-28673, doi: 10.1039/d1ra05463e.
51. Chenxuan Wang#*, Lei Liu*, Xiaoguang Wang*, Editorial: the hierarchical organization of supramolecular systems: from
fundamentals to biomedical applications, Frontiers in Bioengineering and
Biotechnology, 2021, 9, 754980, doi: 10.3389/fbioe.2021.754980.
50. Lanlan
Yu#, Zhun Deng#, Wenbo Zhang, Shuli
Liu, Feiyi Zhang, Jianjian Zhou, Chunhua Ma, Chenxuan Wang*, Opposite Regulatory Effects of immobilized cations
on the folding versus assembly of melittin, Frontiers in Chemistry,
2021, 9, 685947, doi: 10.3389/fchem.2021.685947.
49. Yan Zhao#, Xiaolu Li#, Wenbo Zhang#, Lanlan
Yu#, Yang Wang, Zhun Deng, Mingwei
Liu, Shanshan Mo, Ruonan Wang, Jinming Zhao, Shuli Liu, Yun Hao, Xiangdong
Wang, Tianjiao Ji*, Luo Zhang*, Chenxuan
Wang*, Trends in the biological functions and medical applications of
extracellular vesicles and analogues, Acta Pharmaceutica Sinica B, 2021,
11(8), 2114-2135, doi: 10.1016/j.apsb.2021.03.012.
48. Lanlan
Yu#, Yongfang Zheng, Xiaocui Fang,
Yimin Zou, Chenxuan Wang*, Yanlian
Yang*, Chen Wang*, Composition-dependent multivalency of peptide-peptide interactions
revealed by tryptophan-scanning mutagenesis, Journal of Peptide Science,
2021, 27, e3310, doi:
10.1002/psc.3310.
47. Shan He#, Xinyue He, Lei Liu, Wenbo Zhang,
Lanlan Yu, Zhun Deng, Zhang Feiyi, Shanshan Mo, Yue Fan, Xinyue Zhao, Lun Wang, Chenxuan Wang*, Shuyang Zhang*, The structural understanding of transthyretin
misfolding and the inspired drug approaches for the treatment of heart failure
associated with transthyretin amyloidosis, Frontiers in Pharmacology, 2021, 12, 628184, doi:
10.3389/fphar.2021.628184.
46. Chenxuan Wang#, Naomi A.
Biok, Karthik Nayani, Xiaoguang Wang, Hongseung Yeon, Chi-Kuen Derek Ma, Samuel
H. Gellman*, Nicholas L. Abbott*, Cationic side chain identity directs
the hydrophobically driven self-assembly of amphiphilic β-peptides in aqueous solution, Langmuir, 2021, 37,
3288-3298, doi: 10.1021/acs.langmuir.0c03255.
2020
Publications
45. Lanlan
Yu#, Wenbo Zhang, Wendi Luo, Robert
L. Dupont, Yang Xu, Yibing Wang, Bin Tu, Haiyan Xu, Xiaoguang Wang, Qiaojun
Fang*, Yanlian Yang, Chen Wang, Chenxuan Wang*, Molecular recognition
of human islet amyloid polypeptide assembly by selective oligomerization of
thioflavin T, Science Advances, 2020, 6(32),
eabc1449, doi: 10.1126/sciadv.abc1449.
44. Wenbo
Zhang#, Shanshan Mo#, Mingwei Liu#, Lei Liu, Lanlan Yu*, Chenxuan
Wang*, Rationally designed protein building blocks for programmable
hierarchical architectures, Frontiers in Chemistry, 2020, 8, 587975, doi:
10.3389/fchem.2020.587975.
43. Lanlan
Yu#, Zhun Deng#, Lei Liu, Wenbo Zhang*, Chenxuan Wang*, Plant-derived
nanovesicles: a novel form of nanomedicine, Frontiers in Bioengineering and
Biotechnology, 2020, 8,
584391, doi: 10.3389/fbioe.2020.584391.
42. Wenbo
Zhang#, Lanlan Yu, Tianjiao Ji*, Chenxuan
Wang*, Tumor microenvironment-responsive peptide based supramolecular drug
delivery system, Frontiers in Chemistry, 2020, 8, 549, doi: 10.3389/fchem.2020.00549.
41.
Hongseung Yeon#, Chenxuan Wang, Samuel H. Gellman*, Nicholas L. Abbott*, Influence of immobilized cations on
the thermodynamic signature of hydrophobic interactions at chemically
heterogeneous surfaces, Molecular Systems Design and Engineering,
2020, 5(4), 835-846,
doi: 10.1039/d0me00016g.
40. Qize
Xuan#, Jiaxin He, Min Li, Ruoshi
Chai, Chenxuan Wang*, Yibing Wang*, Ping Wang, Monomer-targeting
affinity peptide inhibitors of amyloid with no self-fibrillation and low
cytotoxicity, Chemical Communications, 2020, 56(11), 1633-1636, doi: 10.1039/c9cc08671d.
2019
Publications
39. Naomi A.
Biok#, Alexander D. Passow, Chenxuan Wang, Craig A. Bingman,
Nicholas L. Abbott*, Samuel H.
Gellman*, Retention of coiled-coil
dimer formation in the absence of ion pairing at positions flanking the
hydrophobic core, Biochemistry, 2019, 58(48),
4821-4826, doi: 10.1021/acs.biochem.9b00668.
38. Chenxuan Wang#, Travis Nelson, Dayue Chen, Joseph
Christopher Ellis, Nicholas L. Abbott*,
Understanding Lipopolysaccharide Aggregation and its Influence on Activation of
Factor C, Journal of Colloid and Interface Science, 2019, 552,
540-553, doi: 10.1016/j.jcis.2019.05.013.
37. Xiaoyun
Li#, Zhu Liang#, Jianchao Du#, Zhiqing
Wang, Song Mei, Zhiqing Li, Yan Zhao, Dandan Zhao, Yiming Ma, Jun Ye, Jiantao
Xu, Yu Zhao, Jiahui Chang, Yuhao Qin, Lanlan Yu, Chenxuan Wang*, Chengyu
Jiang*, Herbal decoctosome is a
novel form of medicine, Science China-Life Sciences, 2019, 62(3),
333-348, doi: 10.1007/s11427-018-9508-0.
36. Zhihui
Yao#, Brian P. Cary, Craig A.
Bingman, Chenxuan Wang, Dale F. Kreitler, Kenneth A. Satyshur, Katrina
T. Forest, Samuel H. Gellman*, Use
of a stereochemical strategy to probe the mechanism of phenol-soluble modulin
alpha 3 toxicity, Journal of the American Chemical Society, 2019, 141(19), 7660-7664, doi: 10.1021/jacs.9b00349.
35. Qunxing
Huang#, Qiong Zhao, Jiaxi Peng,
Ooolalla Yu, Chenxuan Wang, Yimin Zou, Yanlei Su, Ling Zhu*, Chen Wang*, Yanlian Yang*,
Peptide-polyphenol (KLVFF/EGCG) binary modulators for inhibiting aggregation
and neurotoxicity of amyloid-beta peptide, ACS Omega, 2019, 4(2),
4233-4242, doi: 10.1021/acsomega.8b02797.
2018
Publications
34. Reza
Abbasi#, Chenxuan Wang, Yiqun
Bai, Nicholas L. Abbott*,
Phosphorylation status of peptide monolayers modulates hydrogen bonding and
orientations of nematic liquid crystals, Liquid Crystal, 2018, 45 (13-15), 2253-2268, doi: 10.1080/02678292.2018.1509389.
2017
Publications
33. Chenxuan Wang#, C. Derek Ma, Hongseung Yeon, Xiaoguang
Wang, Samuel H. Gellman*, Nicholas
L. Abbott*, Nonadditive interactions
mediated by water at chemically heterogeneous surfaces: nonionic polar groups
and hydrophobic interactions, Journal of the American Chemical Society,
2017, 139(51), 18536-18544,
doi: 10.1021/jacs.7b08367.
32.
Hongseung Yeon#, Chenxuan Wang, Reid C. Van Lehn,
Nicholas L. Abbott*, Influence of
order within nonpolar monolayers on hydrophobic interactions, Langmuir,
2017, 33(19), 4628-4637, doi:
10.1021/acs.langmuir.7b00226.
31. Timothy
J. Smith#, Chenxuan Wang, Nicholas L. Abbott*, Redox-triggered mixing and demixing of surfactants within
assemblies formed in solution and at surfaces, Journal of Colloid and Interface
Science, 2017, 502,
122-133, doi: 10.1016/j.jcis.2017.04.052.
30. Aihua
Yang#, Chenxuan Wang, Baomin Song, Wendi Zhang, Yuanyuan Guo, Rong Yang,
Guangjun Nie, Yanlian Yang*, Chen
Wang*, Attenuation of beta-amyloid
toxicity in vitro and in vivo by accelerated aggregation, Neuroscience Bulletin, 2017, 33(4), 405-412, doi:
10.1007/s12264-017-0144-z.
2016
Publications
29. C. Derek
Ma#, Claribel Acevedo-Vélez, Chenxuan Wang, Samuel H. Gellman*, Nicholas L. Abbott*, Interaction of the hydrophobic tip
of an atomic force microscope with oligopeptides immobilized using short and
long tethers, Langmuir, 2016, 32(12),
2985-2995, doi: 10.1021/acs.langmuir.5b04618.
28. Juan Liu#, Tuo Wei, Jing Zhao, Yuanyu Huang,
Hua Deng, Anil Kumar, Chenxuan Wang,
Zicai Liang, Xiaowei Ma, Xingjie Liang*,
Multifunctional aptamer-based nanoparticles for targeted drug delivery to
circumvent cancer resistance, Biomaterials, 2016, 91, 44-56, doi:
10.1016/j.biomaterials.2016.03.013.
2015
Publications
27. C. Derek
Ma#, Chenxuan Wang, Claribel Acevedo-Vélez, Samuel H. Gellman*, Nicholas L. Abbott*, Modulation of hydrophobic
interactions by proximally immobilized ions, Nature, 2015, 517(7534), 347-U443 doi:
10.1038/nature14018.
26. Yanmei
Wang#, Chenxuan Wang#, Zhiqiang Cheng, Dongdong Zhang, Shaopeng Li,
Lusheng Song, Wenfei Zhou, Mo Yang, Zhiyou Wang, Zheng Zheng, Baohang Han, Chen
Wang*, Yanlian Yang*, Jinsong Zhu*, SPRi determination of inter-peptide interaction by using 3D
supramolecular co-assembly polyrotaxane film, Biosensors and Bioelectronics,
2015, 66, 38-44, doi:
10.1016/j.bios.2014.11.025.
25. Timothy
J. Smith#, Chenxuan Wang, Nicholas L. Abbott*, Influence of self-assembling redox mediators on charge transfer
at hydrophobic electrodes, Langmuir, 2015, 31(39), 10638-10648, doi:
10.1021/acs.langmuir.5b02212.
24. Yang Sun#, Feng Guo, Zhen Zou, Chenggang Li,
Xiaoxu Hong, Yan Zhao, Chenxuan Wang,
Hongliang Wang, Haolin Liu, Peng Yang, Zongsheng Han, Kangtai Liu, Keiji Kuba,
Bin Song, Jinming Gao, Ziyao Mo, Dangsheng Li, Bo Li, Qihan Li, Nanshan Zhong,
Chen Wang, Josef M. Penninger, Chengyu Jiang*, Cationic nanoparticles directly bind angiotensin-converting
enzyme 2 and induce acute lung injury in mice, Particle and Fibre Toxicology,
2015, 12, 4, doi:
10.1186/s12989-015-0080-x.
2014
Publications
23. Yiqun
Bai#, Reza Abbasi, Chenxuan Wang, Nicholas L. Abbott*, Liquid crystals anchored on mixed
monolayers of chiral versus achiral molecules: continuous change in orientation
as a function of enantiomeric excess, Angewandte Chemie International Edition,
2014, 53 (31), 8079-8083, doi:
10.1002/anie.201402770.
22. Huiwen
Du#, Denghua Li, Yibin Wang, Chenxuan Wang, Ping Li, Yanlian Yang*, Chen Wang*, Peptide-assisted directional adsorption of purple membrane at
the liquid-solid interface, Journal of Physical Chemistry C,
2014, 118 (51), 29770-29776, doi: 10.1021/jp5077017.
2013
Publications
21. Min
Zhang#, Xiaobo Mao, Chenxuan Wang, Wenfeng Zeng, Chunling
Zhang, Zhongjun Li, Ying Fang, Yanlian Yang*,
Wei Liang*, Chen Wang*, The effect of graphene oxide on
conformation change, aggregation and cytotoxicity of HIV-1 regulatory protein
(Vpr), Biomaterials, 2013, 34 (4), 1383-1390, doi:
10.1016/j.biomaterials.2012.10.067.
20. Min
Zhang#, Xiaobo Mao, Yue Yu, Chenxuan Wang, Yanlian Yang*, Chen Wang*, Nanomaterials for reducing amyloid cytotoxicity, Advanced
Materials, 2013, 25(28),
3780-3801, doi: 10.1002/adma.201301210.
19. Huiwen
Du#, Denghua Li, Yibing Wang, Chenxuan Wang, Dongdong Zhang, Yanlian
Yang*, Chen Wang*, Determination of the surface charge density and temperature
dependence of purple membrane by electric force microscopy, Journal
of Physical Chemistry B, 2013, 117(34), 9895-9899, doi: 10.1021/jp403075w.
18. Ting
Zhou#, Axel Llizo, Ping Li, Chenxuan Wang, Yuanyuan Guo, Mingqi Ao,
Linling Bai, Chen Wang*, Yanlian
Yang*, Guiying Xu*, High transfection efficiency of
homogeneous DNA nanoparticles induced by imidazolium gemini surfactant as
nonviral vector, Journal of Physical Chemistry C, 2013, 117(50), 26573-26581, doi: 10.1021/jp4061363.
2012
Publications
17. Chenxuan Wang#, Aihua
Yang, Xia Li, Denghua Li, Min Zhang, Huiwen Du, Chao Li, Yuanyuan Guo, Xiaobo
Mao, Mingdong Dong, Flemming Besenbacher, Yanlian Yang*, Chen Wang*,
Observation of molecular inhibition and binding structures of amyloid peptides, Nanoscale, 2012, 4(6), 1895-1909, doi: 10.1039/c2nr11508e.
16. Yuanyuan
Guo#, Chenxuan Wang, Jingfei Hou, Aihua Yang, Xuemei Zhang, Yibing Wang,
Min Zhang, Yanlian Yang*, Chen Wang*, Odd-even sequence effect of
surface-mediated peptide assemblies observed by scanning tunneling microscopy, Chinese
Journal of Chemistry, 2012, 30 (9),
1987-1991, doi: 10.1002/cjoc.201200656.
15. Jie Song#, Menglin Chen, Viduthalai Regina, Chenxuan Wang, Rikke Meyer, Erqing Xie,
Chen Wang, Flemming Besenbacher, Mingdong Dong*, Safe and effective Ag nanoparticles immobilized antimicrobial
nanononwovens, Advanced Engineering Materials, 2012, 14(5),
B240-B246, doi: 10.1002/adem.201180085.
14. Peng Liu#, Shuai Zhang, Meisha Chen, Qian Liu, Chenxuan Wang, Chen Wang, Yanmei Li*, Flemming Besenbacher, Mingdong Dong*, Co-assembly of human islet amyloid
polypeptide (hIAPP)/insulin, Chemical Communications, 2012,
48(2), 191-193, doi: 10.1039/c1cc14285b.
2011
Publications
13. Xiaobo
Mao#, Chenxuan Wang#, Xingkui Wu, Lei Liu, Lan Zhang, Lin Niu, Yanlian
Yang*, Chen Wang*, Beta structure motifs of islet amyloid polypeptides identified
through surface-mediated assemblies, Proceedings of the National Academy of
Sciences of the USA, 2011, 108(49),
19605-19610, doi: 10.1073/pnas.1102971108.
12. Chenxuan Wang#, Xiaobo Mao#, Aihua Yang, Lin Niu, Shengnan Wang,
Denghua Li, Yuanyuan Guo, Yibin Wang, Yanlian Yang*, Chen Wang*,
Determination of relative binding affinities of labeling molecules with amino
acids by using scanning tunneling microscopy, Chemical Communications,
2011, 47(38), 10638-10640, doi:
10.1039/c1cc12380g.
11. Xiaobo
Mao#, Chenxuan Wang, Xiaojing Ma, Min Zhang, Lei Liu, Lan Zhang, Lin Liu,
Qingdao Zeng, Yanlian Yang*, Chen
Wang*, Molecular level studies on
binding modes of labeling molecules with polyalanine peptides, Nanoscale,
2011, 3(4), 1592-1599, doi: 10.1039/c0nr00782j.
10. Xiaobo
Mao#, Yuanyuan Guo, Chenxuan Wang, Min Zhang, Xiaojing Ma,
Lei Liu, Lin Liu, Qingdao Zeng, Yanlian Yang*, Chen Wang*, Binding
modes of thioflavin T molecules to prion peptide assemblies identified by using
scanning tunneling microscopy, ACS Chemical Neuroscience, 2011,
2(6), 281-287, doi: 10.1021/cn200006h.
9. Zengguang
Cheng#, Qiaoyu Zhou, Chenxuan Wang, Qiang Li, Chen Wang,
Ying Fang*, Toward intrinsic
graphene surfaces: a systematic study on thermal annealing and wet-chemical
treatment of SiO2-supported graphene devices, Nano Letter,
2011, 11(2), 767-771, doi: 10.1021/nl103977d.
8. Jie Song#, Menglin Chen, Mikkel Buster Olesen, Chenxuan Wang, Rasmus Havelund, Qiang
Li, Erqing Xie, Rong Yang, Peter Boggild, Chen Wang, Flemming Besenbacher,
Mingdong Dong*, Direct
electrospinning of Ag/polyvinylpyrrolidone nanocables, Nanoscale,
2011, 3(12), 4966-4971, doi: 10.1039/c1nr10512d.
7. Weiwei He#, Shuai Hou, Xiaobo Mao, Xiaochun Wu*, Yinglu Jin, Jianbo Liu, Xiaona Hu,
Ke Zhang, Chenxuan Wang, Yanlian
Yang, Qi Wang, Peptide-tailored assembling of Au nanorods, Chemical
Communications, 2011, 47(19), 5482-5484, doi: 10.1039/c1cc10394f.
2010
Publications
6. Xiaobo
Mao#, Chenxuan Wang, Lei Liu, Xiaojing Ma, Lin Niu, Yanlian Yang*, Chen Wang*, Study on the fine structure of polypeptides at solid-liquid
interfaces by scanning tunneling microscopy, Acta Physico-Chimica Sinica,
2010, 26(4), 850-861, doi: 10.3866/PKU.WHXB20100440.
5. Xuemei
Zhou#, Hongchao Yang, Chenxuan Wang, Yinfang Cui, Xiaobo Mao,
Cong Wang, Yinshu Wang, Gang Liu*,
Visible light induced photocatalytic degradation rhodamine B on one-dimensional
iron oxide particles, Journal of Physical Chemistry C,
2010, 114(40), 17051-17061, doi: 10.1021/jp103816e.
4. Xiaobo
Mao#, Hongchao Yang, Xuemei Zhou, Chenxuan Wang, Yinshu Wang, Yanlian
Yang, Chen Wang, Gang Liu*, Straight
and Branched Goethite Topology by Oriented Attachment at High pH, Crystal
Growth & Design, 2010, 10(2), 504-509, doi: 10.1021/cg900392m.
3.
Tao Zhang#, Zengguang Cheng, Yibing
Wang, Zhongjun Li, Chenxuan Wang,
Yibao Li, Ying Fang*, Self-assembled
1-octadecanethiol monolayers on graphene for mercury detection, Nano Letters, 2010, 10(11), 4738-4741, doi:
10.1021/nl1032556.
2. Hongchao
Yang#, Xuemei Zhou, Tengteng Tang,
Xiaoying Qi, Chenxuan Wang, Jinyao
Lan, Yinshu Wang, Yanlian Yang, Gang Liu*,
Anisotropic growth of multi-twinned goethite particles by oriented aggregation, CrystEngComm, 2010, 12(12), 4007-4009, doi: 10.1039/c0ce00437e.
1.
Jie Jiang#,
Xiaoliang Tang, Wei Dou, Huihui Zhang, Weisheng Liu*, Chenxuan Wang,
Jiangrong Zheng, Synthesis and characterization of the ligand based on
benzoxazole and its transition metal complexes: DNA-binding and antitumor
activity, Journal of
Inorganic Biochemistry, 2010, 104(5), 583-591, doi:
10.1016/j.jinorgbio.2010.01.011.
著作
Books and Chapters
3. Lanlan Yu#, Yanlian Yang, Chen Wang, Chenxuan
Wang*. Peptide Assemblies on
Surfaces: A Study Using Scanning Tunneling Microscopy. In: Xuehai Yan (eds) Peptide
Self-Assembly and Engineering, 2 Volumes: Fundamentals, Structures, and
Applications. 2024, Wiley-VCH, Weinheim, Germany.
2. Wenbo
Zhang#, Lanlan Yu, Chenxuan Wang*. Intermolecular interactions and
self-assembly of peptide-based nanomaterials against human pathogenic bacteria.
In: Haiyan Xu, Ning Gu. (eds) Nanotechnology in regenerative medicine and drug
delivery therapy. 2020, Springer, Singapore
1. 王晨轩#，杨延莲*，王琛*. 《纳米生物医学光电子学前沿》第七章《淀粉样蛋白的结构分析研究进展》科学出版社，2013年，北京
发明专利
Patents
16. 王晨轩，张文博，王洋，李淑媛. 二甲双胍及其它含胍化合物在逆转Gal-10结晶趋势并缓解相关疾病中应用。国家发明专利. 授权公告日2024-03-19, 专利号 ZL202210534642.4
15. 王晨轩，张罗，莫珊珊，王向东，于兰兰，赵妍，李小璐，张文博，郝蕴. 多肽在制备治疗2型免疫疾病的药物中的应用。国家发明专利. 授权公告日2022-08-19, 专利号 ZL202111008545.3
14. 王晨轩，莫珊珊，于兰兰，张罗，赵妍，王向东，李小璐，张文博，郝蕴. 用于治疗2型免疫疾病的多肽。国家发明专利. 授权公告日2022-08-19, 专利号 ZL202111008519.0
13. 王晨轩，于兰兰，王若楠，许海燕，温涛. 一种亲和肽在制备抗冠状病毒药物中的应用。国家发明专利. 授权公告日2022-07-15, 专利号 ZL202110178816.3
12. 王晨轩，莫珊珊，张罗，赵妍，于兰兰，王向东，李小璐，张文博，郝蕴. 靶向夏科-莱登结晶蛋白的多肽及其应用。国家发明专利. 授权公告日2022-05-03, 专利号 ZL202111008517.1
11. 王晨轩，于兰兰，王若楠，许海燕，温涛. 一种亲和肽M5稳定的纳米金颗粒及其制备方法和用途。国家发明专利. 授权公告日2022-04-01, 专利号 ZL202110529881.6
10. 王晨轩，于兰兰，王若楠，许海燕，温涛. 一种新型冠状病毒主蛋白酶的亲和肽M1及其应用。国家发明专利. 授权公告日2022-02-08, 专利号 ZL202110231722.8
9. 王晨轩，于兰兰，王琛，杨延莲. 一种研究蛋白质及药物-蛋白质复合体构象多态性的方法。国家发明专利. 授权公告日2021-03-05,专利号 ZL202010070997.3
8. 王晨轩，邓准，于兰兰，张文博，祖瑞涓，郑明睿. 一种低溶血活性的蜂毒肽及其应用。国家发明专利. 授权公告日2020-04-28,专利号 ZL201910854177.0
7. 王晨轩，邓准，于兰兰，张文博，祖瑞涓，郑明睿. 一种蜂毒肽变体及其应用。国家发明专利. 授权公告日2020-05-12,专利号 ZL201910854956.0
6. 王琛，王晨轩，王艳梅，朱劲松，杨延莲. 与gp41蛋白结合的多肽、多肽芯片、其制备方法和应用。国家发明专利. 授权公告日2017-03-01,专利号 ZL201310298420.8
5. 王琛，王晨轩，王艳梅，朱劲松，杨延莲. 与gp120蛋白结合的多肽、多肽芯片、其制备方法和应用。国家发明专利. 授权公告日2017-06-27,专利号 ZL201310298450.9
4. 张敏，李平，王晨轩，杨延莲，王琛. 抑制b淀粉样蛋白聚集和毒性的多肽抑制剂及其应用。国家发明专利. 授权公告日2017-12-12,专利号 ZL201310294070.8
3. 王琛，杨爱华，王晨轩，杨延莲. 调节b淀粉样蛋白生理毒性的多肽。国家发明专利. 授权公告日2017-12-26,专利号 ZL201310421560.X
2. 王琛，张敏，王晨轩，杨延莲. 一种抑制人胰淀素聚集或毒性的多肽、试剂及其应用。国家发明专利. 授权公告日2015-11-25,专利号 ZL201210410206.2
1. 王琛，杨延莲，许海燕，李潇瑾，张卫奇，孟洁，王晨轩. 一种增强肿瘤细胞对抗肿瘤药物敏感性的多肽及其应用。国家发明专利.授权公告日2018-5-4,专利号 ZL201310298419.5
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