李隽，籍贯河北，本科毕业于北京大学医学部基础医学专业，2010年在美国Texas A&M University 获得生物化学与生物物理博士学位。2010-2018年师从于哈佛医学院遗传系David Sinclair教授进行博士后研究。2018年8月至今，受聘于中国医学科学院基础医学研究所/北京协和医学院基础医学院，目前担任生物化学与分子生物学系课题组长，研究员。2018年入选中国医学科学院/北京协和医学院 “高端科技人才”引进专项支持计划“优秀青年人才”。

本课题组主要从事衰老的分子机制和抗衰老干预方法的研究和应用。具体研究方向包括：

     （1）NAD代谢对衰老进程的调控

     （2）细胞衰老的发生机制及调控

     （3）DNA损伤/修复对细胞及机体水平衰老的影响和调控

      目前课题组成员包括助研1名，技术员2名 ，实验室管理员1人，硕士研究生5人，博士生2人。计划招聘助理研究员1名（研究岗），博士后1名, 同时也欢迎对衰老研究有兴趣的本科生或研究生进行交换培养或实习。

      联系方式：北京市东城区东单三条5号，老科研楼 429房间，邮编 100005，Email：jun_li@ibms.pumc.edu.cn

      代表性论文：

1.  Liang N, Jia He, Jiaqi Yan, Xueying Han, Xiaoqian Zhang, Yamei Niu, Wuga Sha, Jun Li*. DBC1 maintains skeletal muscle integrity by enhancing myogenesis and preventing myofiber wasting，Journal of Cachexia, Sarcopenia and Muscle. 2024 Feb;15(1):255-269.

2.     Qing Tan, Xiaoqian Zhang, Shuxiang Li, Wenbin Liu, Jiaqi Yan, Siqi Wang, Feng Cui, Dan Li*, Jun Li*. DMT1 differentially regulates mitochondrial complex activities to reduce glutathione loss and mitigate ferroptosis. Free Radical Biology and Medicine. 207 (2023) 32-44.

3.     Feng Cui^#, Xueying Han^#, Xiaoqian Zhang^#, Siqi Wang, Na Liang, Qing Tan, Wuga Sha, Jun Li*. ML216 Prevents DNA Damage-Induced Senescence by Modulating DBC1–BLM Interaction. Cells. 2023, 12(1), 145.

4.     Qing Tan, Na Liang, Xiaoqian Zhang, Jun Li*. Dynamic aging: channeled through microenvironment. Frontiers in Physiology. 2021, 12:702276.

5.     Evandro F. Fang, Chenglong Xie, Joseph A. Schenkel, Chenkai Wu, Qian Long, Honghua Cui, Yahyah Aman, Johannes Frank, Jing Liao, Huachun Zou, Ninie Y. Wang, Jing Wu, Xiaoting Liu, Tao Li, Yuan Fang, Zhangming Niu, Guang Yang, Jiangshui Hong, Qian Wang, Guobing Chen, Jun Li, Hou-Zao Chen, Lin Kang, Huanxing Su, Brian C. Gilmour, Xinqiang Zhu, Hong Jiang, Na He, Jun Tao, Sean Xiao Leng, Tanjun Tong, Jean Woo*. A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks, Ageing Research Reviews, 2020;101174,

6.     Emma Bolderson*, Joshua T Burgess, Jun Li, Neha S Gandhi, Didier Boucher, Laura V Croft, Samuel Beard, Jennifer J Plowman, Amila Suraweera, Mark N Adams, Ali Naqi, Shu-Dong Zhang, David A Sinclair, Kenneth J O'Byrne, Derek J Richard*. Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage. Nature Communication. 2019;10(1):5501.

7.     Jun Li, Michael S. Bonkowski, Sébastien Moniot, Dapeng Zhang, Basil P. Hubbard, Alvin J.Y. Ling, Luis A. Rajman, Bo Qin, Zhenkun Lou, Vera Gorbunova, L. Aravind, Clemens Steegborn and David A. Sinclair*. A conserved NAD⁺ binding pocket that regulates protein-protein interactions during aging. Science, 2017, 355(6331): 1312-1317.

8.     Evandro Fei Fang, Henok Kassahun, Deborah L. Croteau, Morten Scheibye-Knudsen, Huiming Lu, Raghavendra A. Shamanna, Sumana Kalyanasundaram, Ravi Chand Bollineni, Mark A. Wilson, Wendy B. Iser, Bradley N. Wollman, Marya Morevati, Jun Li, Jesse S. Kerr, Qiping Lu, Tyler B. Waltz, Jane Tian, David A. Sinclair, Mark P. Mattson, Hilde Nilsen, Vilhelm A. Bohr*. NAD+ replenishment significantly improves outcomes in Ataxia telangiectasia models via mitophagy and DNA repair, Cell Metabolism, 2016, 24(4): 566-581.

9.     Hubbard BP, Loh C, Gomes AP, Li J, Lu Q, Doyle TL, Disch JS, Armour SM, Ellis JL, Vlasuk GP, Sinclair DA*. Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism, Cell cycle. 2013,12(14): 2233-2240.

10. Hubbard, P., Gomes, A., Dai, H., Li, J., Case, A., Considine, T., Riera, T., Lee, J., Yen, ES, Lamming, D., Pentelute, B., Schuman, E., Stevens, L., Ling, A., Armour, S., Michan, S., Zhao, H., Jiang, Y., Sweitzer, S., Blum, C., Disch, J., Ng, PY., Howitz, K., Hamaro, Y., Moss, J., Perni, R., Ellis, J., Vlasuk, G. and Sinclair, D.A*. Evidence for a common mechanism of Sirt1 activation by small molecules. Science,2013, 339(6124): 1216-1219.

11. Jun Li and Paul Fitzpatrick*. Regulation of Phenylalanine Hydroxylase: Conformational changes upon phosphorylation detected by H/D exchange and mass spectrometry, Arch Biochem Biophys.2013, 535(2): 115-119.

12. Jun Li, Udayar Ilangovan, Susan Daubner, Andy Hinck, Paul Fitzpatrick*. Direct evidence for a phenylalanine site in the regulatory domain of phenylalanine hydroxylase. Arch Biochem Biophys.2011, 505(2): 250-255.

13. Jun Li, Larry Dangott, and Paul Fitzpatrick*. Regulation of phenylalanine Hydroxylase: Conformational changes upon phenylalanine binding detected by H/D exchange and mass spectrometry. Biochemistry.2010, 49(15): 3327-3335.

14. Jun Li and Paul Fitzpatrick*. Characterization of metal ligand mutants of phenylalanine hydroxylase: Insights into the plasticity of a 2-histidine-1-carboxylate triad. Arch Biochem Biophys. 2008, 475: 164-168.